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J.AlbaceteA.Martnez-AndjarC.CeliktopuzE.SolmazSarN.et al (2021)

10.1146/annurev-med-042320-014032 119 MiuraH.MizuguchiH.Amano-IwashitaM.Maeda-KogureR.NegishiA.SakaiA.et al (2021)

Rimmerman N, et al

The doses sound impressive, but without liposomal or other bioavailability-enhancing technology, a large fraction of that dose is degraded before it reaches systemic circulation

Active pharmacovigilance and public reporting to the DRAP is encouraged

Supplementation of N-acetyl-cysteine (NAC) as an antioxidant cuts contractile enhancement of glucose uptake by half and decreases AMPK phosphorylation by a similar margin [148]