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Notably, although our study is focused on brain tumors, hyperpolarized -[1- 13 C]gluconolactone could potentially be useful in other tumors that have elevated PPP flux, including low-grade gliomas, pancreatic ductal adenocarcinomas, breast and lung cancers (12, 17)

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To confirm this, we conducted in vitro kinase assays using recombinant active GSK3 and the AMPK complexes purified from HEK293 cells pre-treated with the AMPK activator AICAR 33

Glutathione is primarily used for its antioxidant properties, detoxification of harmful substances, supporting immune function, and promoting overall cellular health